Research In Practice Blog
The Research In Practice Blog shares credible and timely commentary on the latest news, research and events in clinical effectiveness. Catch up on our most recent posts below. Check back often for updates!
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In 2025, despite facing uncertainty and challenges, Clinical Futures remained dedicated to our mission of improving children's health through innovative work and research. We want to express our gratitude to our partners and collaborators for their commitment to this common goal.
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In this comparative study, researchers developed strategies for tailored approaches that may contribute to increased adolescent participation in medical decision making for adolescents with type 1 diabetes and sickle cell disease.
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Children’s Hospital of Philadelphia (CHOP) has been approved for $17 million in research funding by the Patient-Centered Outcomes Research Institute (PCORI), to lead a groundbreaking pragmatic trial evaluating management strategies for asymptomatic, non-obstructive kidney stones. The focus of the project will be to determine whether observation or upfront surgery results in less life disruption from asymptomatic kidney stones for children and adults. Researchers will conduct the trial across 30 sites in PCORnet using patient data from over 1,300 patients aged 6 years and older with…
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Researchers developed and implemented of a pediatric pulmonary embolism clinical pathway and pulmonary embolism response teams at CHOP, which led to improved standardizations of PE evaluation and provided rapid multidisciplinary care for intermediate and high-risk PE.
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Personalizing the care setting for pediatric patients with AML can have profound impacts on their treatment experience and outcomes. The AML Care at Home toolkit includes a discharge eligibility assessment tool and outpatient management guidelines for pediatric patients with AML. This toolkit allows patients, caregivers, and clinicians to choose a care setting collaboratively that balances clinical status, practical factors, and patient/caregiver preferences.
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This five-year longitudinal study builds on the previous research by Drs. Gregory and Lorch on preconception health care and Medicaid. This current study will identify patterns of Medicaid enrollment during early adulthood and investigate whether these patterns are associated with states’ adoption of Medicaid expansion. Researchers will quantify the number of months of Medicaid enrollment and the rate of enrollment churn among individuals aged 19 to 25 years.
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The aim of this retrospective cohort study was to examine the impact of intrapartum and early infancy antibiotic exposures on the risk of later childhood infections. The primary exposure was defined as the administration of intravenous antibiotics during labor or to the infant within three days after birth. The study focused on full-term infants who were born without any infections or chronic congenital conditions.
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Children frequently experience sleep issues, which affect their health and learning. Research behind this study developed and tested a Pediatric Primary Care Sleep Screener tool which significantly improved the identification and management of sleep disorders in children.
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IgE-mediated food allergy is the most common cause of anaphylaxis in children, with peanut being a common culprit food. There has been much interest in food allergy prevention following the landmark LEAP study in 2015. In this study, prevention of peanut allergy was observed when peanuts were introduced early to infants with the risk factors atopic dermatitis (or eczema) or egg allergy.
Following the LEAP study, multi-organization consensus guidelines were published, starting with initial early peanut introduction guidelines in 2015, then addendum guidelines in 2017, followed by more recent…
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Antibiotic administration for suspected late-onset infection is common among preterm infants, but most are ultimately found to be uninfected. Antibiotic stewardship efforts are limited by the lack of large-scale data describing contemporary patterns of late antibiotic use among this population.
While considerable attention has been given to neonatal antibiotic stewardship to mitigate the risk of early-onset sepsis, stewardship for late antibiotic use is hindered by the lack of consensus recommendations to guide empiric antibiotic selection, partly due to the low quality of evidence and to…
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A new study published in Pediatrics investigates how researchers from Children’s Hospital of Philadelphia and Clinical Futures have successfully and effectively scaled dental varnish application across the primary care network using iterative quality improvement (QI), electronic health record (EHR) design, and change management strategies.
