Research In Practice Blog
The Research In Practice Blog shares credible and timely commentary on the latest news, research and events in clinical effectiveness. Catch up on our most recent posts below. Check back often for updates!
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Researchers developed and measured computable phenotype or algorithm that can identify pulmonary embolism in children across a data set.
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in Research In Practice Blog.
2024 was another remarkable year for Clinical Futures!
As this year comes to a close, we take a moment to reflect on a busy yet rewarding time for the Center. To celebrate, we are revisiting some of our favorite blog posts from the past year.
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Rotavirus is a highly contagious virus that causes severe illness in infants. The pentavalent rotavirus vaccine (RV5) must be given to babies under 15 weeks, but some NICUs avoid vaccination due to concerns about transmitting the vaccine strain to unvaccinated infants. Clinical Futures experts completed a year-long study of a 100-bed NICU to investigate this risk. Study results show transmission of the vaccine strain was rare and had no clinical consequences for unvaccinated infants. Researchers concluded that the benefits of in-NICU administration of RV5 vaccine to stable, age-eligible…
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Axial disease in youth is a difficult to treat and often underdiagnosed condition affecting the spine and sacroiliac joints. This form of arthritis can cause pain and stiffness in the back and is sometimes mistaken for other conditions. Axial disease is a characteristic component frequently occurring in a group of conditions known as juvenile spondyloarthritis (SpA), the most common form of juvenile arthritis across the world accounting for as much as one-third of all cases. When untreated, these children are at risk of progression to ankylosing spondylitis which can result in fusion of the…
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Researchers from Children’s Hospital of Philadelphia and Vanderbilt University Medical Center were awarded a $7.37 million National Institutes of Health (NIH) RC2 grant to focus on kidney stone disease research. The focus of the project will be to create a novel research tool called the Urinary Stone Disease Hub, known as USDHub, using de-identified patient data from over 230,000 individuals with kidney stone disease across nine health systems in the U.S.
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Organizational Skills Training (OST) is a behavioral, skills training intervention approach used with children who exhibit deficits in organization, time management, and planning (OTMP) skills, associated often with Attention-Deficit/Hyperactivity Disorder (ADHD). OST Tier 2 (OST-T2) is a modification of the original OST program for use in schools that is administered in small groups in the context of a multi-tier support system that involves parents, teachers, educational support staff, and others. This study evaluated the effectiveness of the OST-T2 intervention when implemented by school…
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Pediatrics itself is a medical specialty, and pediatric professionals can further subspecialize in a focused area of expertise. Children’s hospitals offer families the expertise of pediatric subspecialities who work together provide a comprehensive, multidisciplinary approach to care. Such coordinated care is quarterbacked by pediatric hospitalists, who are attending physicians subspecialized in the field of Pediatric Hospital Medicine.
Hospitalists frequently rely on consultations from other subspecialists such as gastroenterologists, cardiologists, and infectious diseases clinicians to…
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Most young children with pneumonia who are well enough to be cared for at home have an infection caused by a virus, which does not need to be treated with antibiotics. Despite this, most children with mild pneumonia who are cared for in the outpatient setting receive an antibiotic. To improve how antibiotics are used for children with pneumonia it is important to understand the reasons why it might be difficult to not use them. A research team set out to identify these reasons.
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Bronchiolitis is an infection of the airways that causes cold-like symptoms and breathing difficulty, and most commonly affects children under 2 years old. It can be severe enough to require oxygen therapy, suctioning, or IV fluids, but guidelines specify limiting the use of continuous pulse oximetry (cSpO2) monitoring only to patients receiving supplemental oxygen. Even so, many pediatric patients for whom cSpO2 is not recommended are receiving it unnecessarily.
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It’s been an exceptional year for CHOP and the Research Institute as our researchers pursue improvements in clinical effectiveness and policy-oriented health services. A great example of this focus is the Pilot Grant Program, a collaboration between Clinical Futures and PolicyLab at Children’s Hospital of Philadelphia. The Pilot Grant Program supports CHOP investigators and researchers in launching research studies associated with clinical effectiveness and policy-oriented health services. Projects designed to investigate disparities and improve equity of healthcare access and outcomes are…
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LGBTQ+ Adolescents experience more significant negative mental health outcomes. Many must navigate social stigma and rejection, and recent surveillance data revealed that fewer than 40% found their homes to be LGBTQ-affirming.
Evidence has demonstrated that family support does affect the mental health outcomes of LGBTQ+ youth, so a team of clinical researchers explored whether family support has an impact on mental health outcomes. A data-driven investigation was conducted to assess whether positive family support mitigates the risk of depressive symptoms and suicidality in this population…
