Dr. Mostoufi-Moab's research program is focused on the impact of cancer on the underlying mechanisms of skeletal maturation and global metabolism after childhood cancer therapy. She investigates the fat-bone relationship as it pertains to enhanced adiposity and metabolic aberrations in childhood cancer survivors after radiation therapy. Her research program has filled scientific gaps by conducting comprehensive studies of musculoskeletal deficits, growth abnormalities, and sarcopenic obesity in long-term survivors of cancer after radiation.
Her other research studies focus on treatment-related growth abnormalities and skeletal deficits in survivors including growth plate disruption in high-risk neuroblastoma and threats to bone accrual in differentiated thyroid cancer.
Lastly, Dr. Mostoufi-Moab treats endocrine tumors with dedicated effort in treating children and adolescents with thyroid cancer. The paucity of research studies on pediatric thyroid cancer demonstrate the need for research on the role of clinical, molecular, and pathological differences in thyroid cancer in children compared to adults. With collaboration, she has used her clinical and epidemiology research experience to study the long-term outcome and impact of thyroid cancer in pediatrics.
A few highlights of recent her research accomplishments include:
- The first study using magnetic resonance diffuse tensor imaging (DTI) to demonstrate the negative long-term impact of cis-retinoic acid, on the pediatric skeleton and marked disruption of growth plate architecture in survivors of high-risk neuroblastoma
- The first longitudinal study delineating skeletal recovery shortly following completion of acute lymphoblastic leukemia treatment in pediatrics; this study documented dramatic recovery of trabecular and cortical density, cortical dimensions, and defined the relationship between changes in bone density and structure
- The first comprehensive epidemiologic endocrine study to demonstrate an increase of endocrine outcomes in childhood cancer survivors with age, particularly after high-risk treatment exposures.
- A comprehensive longitudinal study demonstrating temporal patterns in the risk of chronic health conditions among survivors of childhood cancer