Karen M. Puopolo, MD, PhD

Dr. Puopolo began her neonatal research career investigating mechanisms of virulence in Group B Streptococcus. Her research now focuses on neonatal sepsis epidemiology and risk assessment. She is funded by the National Institutes of Health and the Centers for Disease Control and Prevention to study the impact of neonatal antibiotic exposures on the newborn and early childhood microbiome, and on infant and early childhood health. Dr. Puopolo's achievements include these research highlights:

  • Co-led the collaborative team that developed and validated the multivariate prediction models that form the Neonatal Early-Onset Sepsis Calculator
  • Lead author for revised American Academy of Pediatrics guidelines for management of early-onset sepsis among term and preterm infants
  • Lead author for revised national guidelines for prevention of perinatal Group B Streptococcal disease
  • Faculty member for Vermont-Oxford Network quality collaborative, Choosing Antibiotics Wisely.”

Dr. Puopolo received her undergraduate degree in physics from Yale University, and subsequently MD and PhD degrees from the Tufts University School of Medicine in Boston. She completed Pediatric residency and Neonatal-Perinatal fellowship training at Boston Children’s Hospital. Dr. Puopolo was on the faculty of Harvard Medical School from 2000 - 2014 where she was a physician and laboratory-based researcher at the Brigham and Women’s Hospital and the Channing Laboratory.

Dr. Puopolo lives in Swarthmore, Pennyslvania, with her husband and their four children.

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