Title

Variation in hospital antibiotic prescribing practices for children with acute lymphoblastic leukemia.

Year of Publication

2013

Number of Pages

1633-9

Date Published

2013 Aug

ISSN Number

1029-2403

Abstract

<p>Antibiotic variation among pediatric oncology patients has not been well-described. Identification of significant variability in antibiotic use within this population would warrant evaluation of its clinical impact. We conducted a retrospective cohort study of newly diagnosed patients with pediatric acute lymophoblastic leukemia (ALL) hospitalized from 1999 to 2009 in 39 freestanding US children's hospitals within the Pediatric Health Information System. Medication use data were obtained for the first 30 days from each patient's index ALL admission date. Antibiotic exposure rates were reported as antibiotic days/1000 hospital days. Unadjusted composite broad-spectrum antibiotic exposure rates varied from 577 to 1628 antibiotic days/1000 hospital days. This wide range of antibiotic exposure was unaffected by adjustment for age, gender, race and days of severe illness (adjusted range: 532-1635 days of antibiotic therapy/1000 hospital days). Antibiotic use for children with newly diagnosed ALL varies widely across children's hospitals and is not explained by demographics or illness severity.</p>

DOI

10.3109/10428194.2012.750722

Alternate Title

Leuk. Lymphoma

PMID

23163631

WATCH THIS PAGE

Subscription is not available for this page.