Title

Tamsulosin and spontaneous passage of ureteral stones in children: a multi-institutional cohort study.

Year of Publication

2014

Number of Pages

506-11

Date Published

2014 Aug

ISSN Number

1527-3792

Abstract

<p><strong>PURPOSE: </strong>Tamsulosin is associated with increased passage of ureteral stones in adults but its effectiveness in children is uncertain. We determined the association between tamsulosin and the spontaneous passage of ureteral stones in children.</p>

<p><strong>MATERIALS AND METHODS: </strong>We performed a multi-institutional retrospective cohort study of patients 18 years or younger who presented between 2007 and 2012 with ureteral stones up to 10 mm and who were treated with tamsulosin or oral analgesics alone. The outcome was spontaneous stone passage, defined as radiographic clearance and/or patient report of passage. Subjects prescribed tamsulosin were matched with subjects prescribed analgesics alone, using nearest neighbor propensity score matching to adjust for treatment selection. Conditional logistic regression models were used to estimate the association between tamsulosin and spontaneous passage of ureteral stones, adjusting for stone size and location.</p>

<p><strong>RESULTS: </strong>Of 449 children with ureteral stones 334 were eligible for inclusion, and complete data were available for 274 patients from 4 institutions (99 receiving tamsulosin, 175 receiving analgesics alone). Following case matching, there were no differences in age, gender, weight, height, stone size or stone location between the 99 subjects prescribed tamsulosin and the 99 propensity score matched subjects prescribed analgesics alone. In the tamsulosin cohort 55% of ureteral stones passed, compared to 44% in the analgesics alone cohort (p=0.03). In multivariate analysis adjusting for stone size and location tamsulosin was associated with spontaneous passage of ureteral stones (OR 3.31, 95% CI 1.49-7.34).</p>

<p><strong>CONCLUSIONS: </strong>The odds of spontaneous passage of ureteral stones were greater in children prescribed tamsulosin vs analgesics alone.</p>

DOI

10.1016/j.juro.2014.01.091

Alternate Title

J. Urol.

PMID

24518765

WATCH THIS PAGE

Subscription is not available for this page.