Title

Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease.

Year of Publication

2015

Number of Pages

e135-7

Date Published

03/2015

ISSN Number

1536-3678

Abstract

<p>A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody.</p>

DOI

10.1097/MPH.0000000000000241

Alternate Title

J. Pediatr. Hematol. Oncol.

PMID

25171447

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