Title

Predictors of progression in autosomal dominant and autosomal recessive polycystic kidney disease.

Year of Publication

2021

Date Published

2021 Jan 21

ISSN Number

1432-198X

Abstract

<p>Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are characterized by bilateral cystic kidney disease leading to progressive kidney function decline. These diseases also have distinct liver manifestations. The range of clinical presentation and severity of both ADPKD and ARPKD is much wider than was once recognized. Pediatric and adult nephrologists are likely to care for individuals with both diseases in their lifetimes. This article will review genetic, clinical, and imaging predictors of kidney and liver disease progression in ADPKD and ARPKD and will briefly summarize pharmacologic therapies to prevent progression.</p>

DOI

10.1007/s00467-020-04869-w

Alternate Title

Pediatr Nephrol

PMID

33474686

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