Maternal anxiety and depression in pregnancy and DNA methylation of the glucocorticoid receptor gene.
Year of Publication
2020 Nov 20
<p><strong>Aim: </strong>To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor (<em>NR3C1</em>). <strong>Materials & methods: </strong>Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. <em>NR3C1 </em>methylation was determined at four methylation sites. <strong>Results:</strong> DNA methylation of CpG 1 in the <em>NR3C1 </em>CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and <em>NR3C1 </em>methylation. <strong>Conclusion:</strong> We found that maternal anxiety was associated with increased <em>NR3C1 </em>CpG island shore methylation.</p>