Title

Massive cortical reorganization is reversible following bilateral transplants of the hands: evidence from the first successful bilateral pediatric hand transplant patient.

Year of Publication

2018

Number of Pages

92-97

Date Published

2018 Jan

ISSN Number

2328-9503

Abstract

<p>In this repeated measures case study, we show that sensory deafferentation after limb amputation leads to changes in cortical somatotopic maps which are reversible after restoration of sensory input. Using magnetoencephalography (MEG), we observed in a child with bilateral hand transplants large-scale shifts in somatosensory lip cortical representation from anatomic hand area to anatomic face region. After recovery of tactile sensation in the digits, responses to finger stimulation were localized to orthotopic sensory cortex, but with atypical electrophysiologic features (amplitude and frequencies).</p>

DOI

10.1002/acn3.501

Alternate Title

Ann Clin Transl Neurol

PMID

29376095

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