Title

Glucose concentrations in enterally fed preterm infants.

Year of Publication

2020

Date Published

2020 Aug 05

ISSN Number

1476-5543

Abstract

<p><strong>OBJECTIVES: </strong>Determine the prevalence of glucose concentrations below the Pediatric Endocrine Society (PES) term and late preterm-focused guideline target for mean glucose concentrations (≥70 mg/dL) among preterm NICU infants on full enteral nutrition and assess the impact on monitoring practices.</p>

<p><strong>STUDY DESIGN: </strong>Retrospective cohort study.</p>

<p><strong>RESULTS: </strong>We analyzed 1717 infants who were at least 2 days old and 48 hours after parenteral fluids were discontinued. Glucose concentrations were ≥70, 60-69, 50-59, and &lt;50 mg/dL in 76.6, 16.2, 5.9, and 1.3% of measurements, respectively. In multivariate models, concentrations &lt;60 mg/dL were common among male infants at lower postnatal age, small-for-gestational age, and born to women with hypertension (p &lt; 0.05). After PES guideline, infants were more likely to have &gt;3 glucose measurements (p &lt; 0.05).</p>

<p><strong>CONCLUSIONS: </strong>Glucose concentrations &lt;70 mg/dL are not uncommon among preterm infants receiving full enteral nutrition. Monitoring increased after guideline publication. Applying PES threshold to well-appearing preterm infants may promote increased monitoring and intervention without clear long-term benefit.</p>

DOI

10.1038/s41372-020-0754-6

Alternate Title

J Perinatol

PMID

32759957

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