Title

FDG-PET in two cases of neurofibromatosis type 1 and atypical malignancies.

Year of Publication

2014

Number of Pages

e345-8

Date Published

2014 Apr

ISSN Number

1198-0052

Abstract

<p>Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although (18)F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours.</p>

DOI

10.3747/co.21.1803

Alternate Title

Curr Oncol

PMID

24764718

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