Title

Epidemiology of childhood acute myeloid leukemia.

Year of Publication

2013

Number of Pages

728-33

Date Published

2013 May

ISSN Number

1545-5017

Abstract

<p>Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.</p>

DOI

10.1002/pbc.24464

Alternate Title

Pediatr Blood Cancer

PMID

23303597

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