Title

Elevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.

Year of Publication

2017

Number of Pages

1453-1456

Date Published

2017 May 15

ISSN Number

1537-6591

Abstract

<p>Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.</p>

DOI

10.1093/cid/cix155

Alternate Title

Clin. Infect. Dis.

PMID

28203772

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