Association between Daily Water Intake and 24-hour Urine Volume Among Adolescents with Kidney Stones.

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2020 Jan 28

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<p><strong>OBJECTIVE: </strong>To determine the association between daily water intake and 24-hour urine volume among adolescents with nephrolithiasis in order to estimate a "fluid prescription", the additional water intake needed to increase urine volume to a target goal.</p>

<p><strong>METHODS: </strong>We conducted a secondary analysis of an ecological momentary assessment study that prospectively measured daily water intake of 25 adolescents with nephrolithiasis over 7 days. We identified 24-hour urine volumes obtained for clinical care within 12 months of water intake assessment. A linear regression model was fit to estimate the magnitude of the association between daily water intake and 24-hour urine volume, adjusting for age, sex, race, and daily temperature.</p>

<p><strong>RESULTS: </strong>Twenty-two participants completed fifty-seven 24-hour urine collections within 12 months of the study period. Median daily water intake was 1.4 L (IQR 0.67-1.94). Median 24-hour urine volume was 2.01 L (IQR 1.20-2.73). A 1 L increase in daily water intake was associated with a 710 mL increase in 24-hour urine output (95% CI 0.55-0.87). Using the model output, the equation was generated to estimate the additional fluid intake needed (fluid prescription; FP) to produce the desired increase in urine output (dUOP): FP=dUOP/0.71.</p>

<p><strong>CONCLUSIONS: </strong>The fluid prescription equation (FP = dUOP)/0.71), which reflects the relationship between water intake and urine volume, could be used to help adolescents with nephrolithiasis achieve urine output goals to decrease stone recurrence.</p>



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