Title

Administration and Dosing of Systemic Antifungal Agents in Pediatric Patients.

Year of Publication

2020

Date Published

2020 Jan 23

ISSN Number

1179-2019

Abstract

<p>Neonates and immunosuppressed/immunocompromised pediatric patients are at high risk of invasive fungal diseases. Appropriate antifungal selection and optimized dosing are imperative to the successful prevention and treatment of these life-threatening infections. Conventional amphotericin B was the mainstay of antifungal therapy for many decades, but dose-limiting nephrotoxicity and infusion-related adverse events impeded its use. Despite the development of several new antifungal classes and agents in the past 20&nbsp;years, and their now routine use in at-risk pediatric populations, data to guide the optimal dosing of antifungals in children are limited. This paper reviews the spectra of activity for approved antifungal agents and summarizes the current literature specific to pediatric patients regarding pharmacokinetic/pharmacodynamic data, dosing, and therapeutic drug monitoring.</p>

DOI

10.1007/s40272-020-00379-2

Alternate Title

Paediatr Drugs

PMID

31974859

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