First name
Katelyn
Last name
Oranges

Title

Guideline for Children With Cancer Receiving General Anesthesia for Procedures and Imaging.

Year of Publication

2022

Date Published

2022 Mar 01

ISSN Number

1536-3678

Abstract

<p>Children with cancer and those undergoing hematopoietic stem cell transplantation frequently require anesthesia for imaging as well as diagnostic and therapeutic procedures from diagnosis through follow-up. Due to their underlying disease and side effects of chemotherapy and radiation, they are at risk for complications during this time, yet no published guideline exists for preanesthesia preparation. A comprehensive literature review served as the basis for discussions among our multidisciplinary panel of oncologists, anesthesiologists, nurse practitioners, clinical pharmacists, pediatric psychologists, surgeons and child life specialists at the Children's Hospital of Philadelphia. Due to limited literature available, this panel created an expert consensus guideline addressing anesthesia preparation for this population.</p>

DOI

10.1097/MPH.0000000000002430

Alternate Title

J Pediatr Hematol Oncol

PMID

35235547

Title

Acute Left Ventricular Dysfunction Following Gemtuzumab Ozogamicin in Two Pediatric AML Patients.

Year of Publication

2022

Number of Pages

e507-e511

Date Published

2022 Mar 01

ISSN Number

1536-3678

Abstract

<p>Gemtuzumab ozogamicin (GO) is an anti-CD33 antibody-tumor antibiotic conjugate with proven efficacy in pediatric and adult patients with CD33+ acute myeloid leukemia. Adverse effects commonly associated with GO include hyperbilirubinemia, elevated transaminases, and sinusoidal obstruction syndrome. Cardiotoxicity has not been a commonly described adverse event. We describe 2 pediatric patients with relapsed/refractory acute myeloid leukemia who received fractionated GO monotherapy and subsequently developed severe acute left ventricular dysfunction. Both patients achieved remission, recovered cardiac function with medical therapy, and tolerated subsequent stem cell transplantation.</p>

DOI

10.1097/MPH.0000000000002325

Alternate Title

J Pediatr Hematol Oncol

PMID

35200224

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