American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock.

2017

1061-1093

2017 Jun

1530-0293

<p><strong>OBJECTIVES: </strong>The American College of Critical Care Medicine provided 2002 and 2007 guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the 2014 update of the 2007 American College of Critical Care Medicine "Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock."</p>

<p><strong>DESIGN: </strong>Society of Critical Care Medicine members were identified from general solicitation at Society of Critical Care Medicine Educational and Scientific Symposia (2006-2014). The PubMed/Medline/Embase literature (2006-14) was searched by the Society of Critical Care Medicine librarian using the keywords: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation, and American College of Critical Care Medicine guidelines in the newborn and pediatric age groups.</p>

<p><strong>MEASUREMENTS AND MAIN RESULTS: </strong>The 2002 and 2007 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and American Heart Association/Pediatric Advanced Life Support sanctioned recommendations. The review of new literature highlights two tertiary pediatric centers that implemented quality improvement initiatives to improve early septic shock recognition and first-hour compliance to these guidelines. Improved compliance reduced hospital mortality from 4% to 2%. Analysis of Global Sepsis Initiative data in resource rich developed and developing nations further showed improved hospital mortality with compliance to first-hour and stabilization guideline recommendations.</p>

<p><strong>CONCLUSIONS: </strong>The major new recommendation in the 2014 update is consideration of institution-specific use of 1) a "recognition bundle" containing a trigger tool for rapid identification of patients with septic shock, 2) a "resuscitation and stabilization bundle" to help adherence to best practice principles, and 3) a "performance bundle" to identify and overcome perceived barriers to the pursuit of best practice principles.</p>

10.1097/CCM.0000000000002425

Crit. Care Med.

28509730

The Spectrum of Pediatric Sepsis: "Septicemia" Misses Severe Cases.

2015

685-6

2015 Dec

1097-6760

10.1016/j.annemergmed.2015.07.521

Ann Emerg Med

26590745

Pediatric severe sepsis in U.S. children's hospitals.

2014

798-805

11/2014

1529-7535

<p><strong>OBJECTIVES: </strong>To compare the prevalence, resource utilization, and mortality for pediatric severe sepsis identified using two established identification strategies.</p>

<p><strong>DESIGN: </strong>Observational cohort study from 2004 to 2012.</p>

<p><strong>SETTING: </strong>Forty-four pediatric hospitals contributing data to the Pediatric Health Information Systems database.</p>

<p><strong>PATIENTS: </strong>Children 18 years old or younger.</p>

<p><strong>MEASUREMENTS AND MAIN RESULTS: </strong>We identified patients with severe sepsis or septic shock by using two International Classification of Diseases, 9th edition, Clinical Modification-based coding strategies: 1) combinations of International Classification of Diseases, 9th edition, Clinical Modification codes for infection plus organ dysfunction (combination code cohort); 2) International Classification of Diseases, 9th edition, Clinical Modification codes for severe sepsis and septic shock (sepsis code cohort). Outcomes included prevalence of severe sepsis, as well as hospital and ICU length of stay, and mortality. Outcomes were compared between the two cohorts examining aggregate differences over the study period and trends over time. The combination code cohort identified 176,124 hospitalizations (3.1% of all hospitalizations), whereas the sepsis code cohort identified 25,236 hospitalizations (0.45%), a seven-fold difference. Between 2004 and 2012, the prevalence of sepsis increased from 3.7% to 4.4% using the combination code cohort and from 0.4% to 0.7% using the sepsis code cohort (p &lt; 0.001 for trend in each cohort). Length of stay (hospital and ICU) and costs decreased in both cohorts over the study period (p &lt; 0.001). Overall, hospital mortality was higher in the sepsis code cohort than the combination code cohort (21.2% [95% CI, 20.7-21.8] vs 8.2% [95% CI, 8.0-8.3]). Over the 9-year study period, there was an absolute reduction in mortality of 10.9% (p &lt; 0.001) in the sepsis code cohort and 3.8% (p &lt; 0.001) in the combination code cohort.</p>

<p><strong>CONCLUSIONS: </strong>Prevalence of pediatric severe sepsis increased in the studied U.S. children's hospitals over the past 9 years, whereas resource utilization and mortality decreased. Epidemiologic estimates of pediatric severe sepsis varied up to seven-fold depending on the strategy used for case ascertainment.</p>

10.1097/PCC.0000000000000225

Pediatr Crit Care Med

25162514