First name
Kathryn
Middle name
M
Last name
Sundheim

Title

Seasonality of Acute Lyme Disease in Children.

Year of Publication

2021

Number of Pages

Date Published

2021 Nov 09

ISSN Number

2414-6366

Abstract

<p>Due to the life cycle of its vector, Lyme disease has known seasonal variation. However, investigations focused on children have been limited. Our objective was to evaluate the seasonality of pediatric Lyme disease in three endemic regions in the United States. We enrolled children presenting to one of eight Pedi Lyme Net participating emergency departments. Cases were classified based on presenting symptoms: early (single erythema migrans (EM) lesion), early-disseminated (multiple EM lesions, headache, cranial neuropathy, or carditis), or late (arthritis). We defined a case of Lyme disease by the presence of an EM lesion or a positive two-tier Lyme disease serology. To measure seasonal variability, we estimated Fourier regression models to capture cyclical patterns in Lyme disease incidence. While most children with early or early-disseminated Lyme disease presented during the summer months, children with Lyme arthritis presented throughout the year. Clinicians should consider Lyme disease when evaluating children with acute arthritis throughout the year.</p>

DOI

10.3390/tropicalmed6040196

Alternate Title

Trop Med Infect Dis

PMID

34842846
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