First name
David
Last name
Friedman

Title

Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.

Year of Publication

2020

Number of Pages

e28693

Date Published

2020 Sep 04

ISSN Number

1545-5017

Abstract

<p>There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.</p>

DOI

10.1002/pbc.28693

Alternate Title

Pediatr Blood Cancer

PMID

32885904

Title

Visual analytical tool for evaluation of 10-year perioperative transfusion practice at a children's hospital.

Year of Publication

2014

Number of Pages

529-34

Date Published

2014 May-Jun

ISSN Number

1527-974X

Abstract

<p>Children are a vulnerable population in the operating room, and are particularly at risk of complications from unanticipated hemorrhage. The decision to prepare blood products prior to surgery varies depending on the personal experience of the clinician caring for the patient. We present the first application of a data visualization technique to study large datasets in the context of blood product transfusions at a tertiary pediatric hospital. The visual analytical interface allows real-time interaction with datasets from 230 000 procedure records. Clinicians can use the visual analytical interface to analyze blood product usage based on procedure- and patient-specific factors, and then use that information to guide policies for ordering blood products.</p>

DOI

10.1136/amiajnl-2013-002241

Alternate Title

J Am Med Inform Assoc

PMID

24363319

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