First name
Christopher
Last name
Petucci

Title

Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease.

Year of Publication

2020

Date Published

2020 Aug 11

ISSN Number

1934-6069

Abstract

<p>Children with inflammatory bowel diseases (IBD) are particularly vulnerable to infection with Clostridioides difficile (CDI). IBD and IBD&nbsp;+ CDI have overlapping symptoms but respond to distinctive treatments, highlighting the need for diagnostic biomarkers. Here, we studied pediatric patients with IBD and IBD&nbsp;+ CDI, comparing longitudinal data on the gut microbiome, metabolome, and other measures. The microbiome is dysbiotic and heterogeneous in both disease states, but the metabolome reveals disease-specific patterns. The IBD group shows increased concentrations of markers of inflammation and tissue damage compared with healthy controls, and metabolic changes associate with susceptibility to CDI. In IBD&nbsp;+ CDI, we detect both metabolites associated with inflammation/tissue damage and fermentation products produced by C.&nbsp;difficile. The most discriminating metabolite found is isocaproyltaurine, a covalent conjugate of a distinctive C.&nbsp;difficile fermentation product (isocaproate) and an amino acid associated with tissue damage (taurine), which may be useful as a joint marker of the two disease processes.</p>

DOI

10.1016/j.chom.2020.07.020

Alternate Title

Cell Host Microbe

PMID

32822584

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