<p><strong>OBJECTIVES: </strong>To determine the proportion of well-appearing newborns screened for hypoglycemia, yield of specific screening criteria, and impact of screening on breastfeeding.</p>

<p><strong>STUDY DESIGN: </strong>The retrospective study of well-appearing at-risk infants born ≥36 weeks' gestation with blood glucose (BG) measurements obtained ≤72 h of age.</p>

<p><strong>RESULTS: </strong>Of 10,533 eligible well newborns, 48.7% were screened for hypoglycemia. Among tested infants, BG &lt; 50 mg/dL occurred in 43% and 4.6% required intensive care for hypoglycemia. BG &lt; 50 mg/dL was associated with lower rates of exclusive breastfeeding (22% vs 65%, p &lt; 0.001). Infants screened due to late-preterm birth were most frequently identified as hypoglycemic. The fewest abnormal values occurred among appropriate weight, late-term infants of nondiabetic mothers.</p>

<p><strong>CONCLUSION: </strong>Hypoglycemia risk criteria result in screening a large proportion of otherwise well newborns and negatively impact rates of exclusive breastfeeding. The risks and benefits of hypoglycemia screening recommendations should be urgently addressed.</p>