First name
Kanecia
Last name
Zimmerman

Title

Test-to-Stay After SARS-CoV-2 Exposure: A Mitigation Strategy for Optionally Masked K-12 Schools.

Year of Publication

2022

Number of Pages

Date Published

08/2022

ISSN Number

1098-4275

Abstract

OBJECTIVES: We evaluated the impact of a test-to-stay (TTS) program on within-school transmission and missed school days in optionally masked kindergarten through 12th grade schools during a period of high community severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission.

METHODS: Close contacts of those with confirmed SARS-CoV-2 infection were eligible for enrollment in the TTS program if exposure to a non-household contact occurred between 11/29/2021 and 01/28/2022. Consented participants avoided school exclusion if they remained asymptomatic and rapid antigen testing at pre-specified intervals remained negative. Primary outcomes included within-school tertiary attack rate (test positivity among close contacts of positive TTS participants) and school days saved among TTS participants. We estimated the number of additional school-acquired cases resulting from TTS and eliminating school exclusion.

RESULTS: A total of 1675 participants tested positive or received at least one negative test between days 5 and 7, and completed follow-up; 92% were students and 91% were exposed to an unmasked primary case. We identified 201 positive cases. We observed a tertiary attack rate of 10% (95% CI 6-19%) and 7,272 (89%) of potentially missed days were saved through TTS implementation. We estimated one additional school-acquired case for every 21 TTS participants remaining in school buildings during the entire study period.

CONCLUSIONS: Even in the setting of high community transmission, a TTS strategy resulted in substantial reduction in missed school days in optionally masked schools.

DOI

10.1542/peds.2022-058200

Alternate Title

Pediatrics

PMID

35971240
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Title

Outcomes associated with surfactant in more mature and larger premature infants with respiratory distress syndrome.

Year of Publication

2020

Number of Pages

Date Published

2020 Feb 20

ISSN Number

1476-5543

Abstract

<p><strong>OBJECTIVE: </strong>Examine the effect of off-label surfactant on mortality and morbidity in more mature and larger premature infants diagnosed with respiratory distress syndrome (RDS).</p>

<p><strong>STUDY DESIGN: </strong>Cohort study of premature infants born at 30-36 weeks, birth weight &gt; 2 kg, and a diagnosis of RDS. We compared the odds of mortality and morbidity between infants who were exposed vs unexposed to surfactant. We used a treatment effects model to balance covariates between groups.</p>

<p><strong>RESULTS: </strong>Of 54,964 included infants, 25,278 (46%) were exposed to surfactant. The frequency of mortality and morbidities were higher in the exposed group in unadjusted analyses. Following adjustment with a doubly robust treatment effects model, we found no significant treatment effect of surfactant on mortality or morbidity.</p>

<p><strong>CONCLUSION: </strong>Surfactant exposure is not associated with reduced or increased mortality or morbidity in more mature premature infants with RDS.</p>

DOI

10.1038/s41372-020-0625-1

Alternate Title

J Perinatol

PMID

32080333
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