First name
David
Last name
Langdon

Title

Vitamin D status in abused and nonabused children younger than 2 years old with fractures.

Year of Publication

2011

Number of Pages

835-41

Date Published

2011 May

ISSN Number

1098-4275

Abstract

<p><strong>OBJECTIVE: </strong>To examine vitamin D levels in children with (1) suspected abusive and accidental fractures, (2) single and multiple fractures, and (3) fracture types highly associated with inflicted trauma.</p>

<p><strong>DESIGN AND METHODS: </strong>A study of children younger than 2 years of age with fractures admitted to a large children's hospital was performed. Bivariate analysis and test for trend were performed to test for the association of vitamin D status and biochemical markers of bone health with the primary outcomes of fracture etiology, number, and type.</p>

<p><strong>RESULTS: </strong>Of 118 subjects in the study, 8% had deficient vitamin D levels (&lt;20 ng/mL; &lt;50 nmol/L), 31% were insufficient (≥20 &lt; 30 ng/mL; ≥50 &lt; 78 nmol/L), and 61% were sufficient (≥30 ng/mL; ≥78 nmol/L). Lower vitamin D levels were associated with higher incidences of hypocalcemia (P = .002) and elevated alkaline phosphatase (P = .05) but not hypophosphatemia (P = .30). The majority of children sustained accidental fractures (60%); 31% were nonaccidental and 9% were indeterminate. There was no association between vitamin D levels and any of the following outcomes: child abuse diagnosis (P = .32), multiple fractures (P = .24), rib fractures (P = .16), or metaphyseal fractures (P = .49).</p>

<p><strong>CONCLUSIONS: </strong>Vitamin D insufficiency was common in young children with fractures but was not more common than in previously studied healthy children. Vitamin D insufficiency was not associated with multiple fractures or diagnosis of child abuse. Nonaccidental trauma remains the most common cause of multiple fractures in young children.</p>

DOI

10.1542/peds.2010-0533

Alternate Title

Pediatrics

PMID

21482609

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