First name
Edward
Middle name
J
Last name
Doolin

Title

Case report: Ampicillin-induced stone formation causing bilateral ureteral obstruction during pelvic surgery.

Year of Publication

2019

Number of Pages

100851

Date Published

2019 May

ISSN Number

2214-4420

Abstract

<p>Numerous medications can predispose patients to stone formation. Some induce metabolic changes that alter urine chemistries, such as topiramate, which can cause a mixed renal tubular acidosis. Others or their breakdown products form stones composed of the drugs themselves, like those that are renally excreted and become supersaturated in the urine in a favorable environment. Like all stones, they can cause obstruction and infection.</p>

<p>Here we present a case of ampicillin stone formation in an 11-year-old girl during a pelvic reconstructive procedure, which required ureteral stenting to prevent obstruction from an institutional guideline's perioperative antimicrobial dosing. While there are many reports of amoxicillin and ampicillin crystalluria, there is only one account in the literature of an adult with resultant ureteral obstruction requiring intervention. Our case is the first report, to our knowledge, in a child, and highlights the potential for significant crystal formation and if unrecognized, complete urinary obstruction. Since ampicillin is a commonly administered perioperatively, awareness of ampicillin stone formation during surgery is important.</p>

DOI

10.1016/j.eucr.2019.100851

Alternate Title

Urol Case Rep

PMID

31211062
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