First name
Anna
Last name
Chamby

Title

High Rate of Serotype V Carriage in Pregnant Women in Botswana.

Year of Publication

2019

Date Published

2019 Mar 25

ISSN Number

1476-1645

Abstract

<p>Maternal rectovaginal colonization is the major risk factor for early-onset neonatal sepsis due to Group B (GBS), a major cause of early life morbidity and mortality. Transmission generally occurs perinatally from colonized mothers to infants. Vaccines targeting a subset of GBS serotypes are under development, but GBS epidemiology remains poorly understood in many African nations. We performed a cross-sectional study of GBS colonization among pregnant women at two sites in Botswana, a country with minimal prior GBS carriage data. We found a rectovaginal colonization rate of 19%, comparable with studies in other regions; however, we also noted a striking predominance of serotype V (&gt; 45% of strains). Although further studies are required to delineate the burden of invasive GBS disease in Botswana and the generalizability of type V epidemiology, these data provide a useful baseline for understanding the potential local impact of GBS prevention strategies, including vaccines.</p>

DOI

10.4269/ajtmh.18-0847

Alternate Title

Am. J. Trop. Med. Hyg.

PMID

30915949

WATCH THIS PAGE

Subscription is not available for this page.