First name
David
Last name
Miedema

Title

Glucose concentrations in enterally fed preterm infants.

Year of Publication

2020

Date Published

2020 Aug 05

ISSN Number

1476-5543

Abstract

<p><strong>OBJECTIVES: </strong>Determine the prevalence of glucose concentrations below the Pediatric Endocrine Society (PES) term and late preterm-focused guideline target for mean glucose concentrations (≥70 mg/dL) among preterm NICU infants on full enteral nutrition and assess the impact on monitoring practices.</p>

<p><strong>STUDY DESIGN: </strong>Retrospective cohort study.</p>

<p><strong>RESULTS: </strong>We analyzed 1717 infants who were at least 2 days old and 48 hours after parenteral fluids were discontinued. Glucose concentrations were ≥70, 60-69, 50-59, and &lt;50 mg/dL in 76.6, 16.2, 5.9, and 1.3% of measurements, respectively. In multivariate models, concentrations &lt;60 mg/dL were common among male infants at lower postnatal age, small-for-gestational age, and born to women with hypertension (p &lt; 0.05). After PES guideline, infants were more likely to have &gt;3 glucose measurements (p &lt; 0.05).</p>

<p><strong>CONCLUSIONS: </strong>Glucose concentrations &lt;70 mg/dL are not uncommon among preterm infants receiving full enteral nutrition. Monitoring increased after guideline publication. Applying PES threshold to well-appearing preterm infants may promote increased monitoring and intervention without clear long-term benefit.</p>

DOI

10.1038/s41372-020-0754-6

Alternate Title

J Perinatol

PMID

32759957

Title

NICU Admissions After a Policy to Eliminate Elective Early Term Deliveries Before 39 Weeks' Gestation.

Year of Publication

2018

Number of Pages

686-692

Date Published

2018 Nov

ISSN Number

2154-1663

Abstract

<p><strong>BACKGROUND AND OBJECTIVES: </strong>Early term infants (37-&lt;39 weeks' gestation) are at higher risk of adverse outcomes than term infants (39-&lt;41 weeks' gestation). We hypothesized that a policy to eliminate elective, early term deliveries would result in fewer NICU admissions and shorter lengths of stay among infants born ≥37 weeks.</p>

<p><strong>METHODS: </strong>This was a retrospective cohort study of singleton infants born ≥37 weeks at a tertiary medical center from 2004 to 2015 (preperiod: 2004-2008; postperiod: 2010-2015; washout period: 2009). We compared the incidence of early term delivery, NICU admissions (short: ≥4-&lt;24 hours, long: ≥24 hours), NICU diagnoses, and stillbirths in both periods. We used modified Poisson regression to calculate adjusted risk ratios.</p>

<p><strong>RESULTS: </strong>There were 20 708 and 24 897 singleton infants born ≥37 weeks in the pre- and postperiod, respectively. The proportion of early term infants decreased from 32.5% to 25.7% ( &lt; .0001). NICU admissions decreased nonsignificantly (9.2% to 8.8%; = .22), with a significant reduction in short NICU stays (5.4% to 4.6%; adjusted risk ratio: 0.85 [95% confidence interval: 0.79-0.93]). Long NICU stays increased slightly (3.8% to 4.2%), a result that was nullified by adjusting for neonatal hypoglycemia. A nonsignificant increase in the incidence of stillbirths ≥37 to &lt;40 weeks was present in the postperiod (7.5 to 10 per 10 000 births; = .46).</p>

<p><strong>CONCLUSIONS: </strong>Reducing early term deliveries was associated with fewer short NICU stays, suggesting that efforts to discourage early term deliveries in uncomplicated pregnancies may minimize mother-infant separation in the newborn period.</p>

DOI

10.1542/hpeds.2018-0068

Alternate Title

Hosp Pediatr

PMID

30361206

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