First name
James
Middle name
W
Last name
Collins

Title

States with more killings of unarmed Black people have larger Black-White preterm birth disparities.

Year of Publication

2021

Number of Pages

Date Published

2021 Jan 15

ISSN Number

1476-5543

DOI

10.1038/s41372-020-00914-6

Alternate Title

J Perinatol

PMID

33452418
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Title

The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth.

Year of Publication

2019

Number of Pages

Date Published

2019 Aug 05

ISSN Number

1530-0447

Abstract

<p>Differences in preterm birth rates between black and white women are the largest contributor to racial disparities in infant mortality. In today's age of precision medicine, analysis of the genome, epigenome, metabolome, and microbiome has generated interest in determining whether these biomarkers can help explain racial disparities. We propose that there are pitfalls as well as opportunities when using precision medicine analyses to interrogate disparities in health. To conclude that racial disparities in complex conditions are genetic in origin ignores robust evidence that social and environmental factors that track with race are major contributors to disparities. Biomarkers measured in omic assays that may be more environmentally responsive than genomics, such as the epigenome or metabolome, may be on the causal pathway of race and preterm birth, but omic observational studies suffer from the same limitations as traditional cohort studies. Confounding can lead to false conclusions about the causal relationship between omics and preterm birth. Methodological strategies (including stratification and causal mediation analyses) may help to ensure that associations between biomarkers and exposures, as well as between biomarkers and outcomes, are valid signals. These epidemiologic strategies present opportunities to assess whether precision medicine biomarkers can uncover biology underlying perinatal health disparities.</p>

DOI

10.1038/s41390-019-0528-z

Alternate Title

Pediatr. Res.

PMID

31382269
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Title

Moving beyond race and ethnicity to understand the effect of inhaled nitric oxide on bronchopulmonary dysplasia prevention.

Year of Publication

2018

Number of Pages

Date Published

2018 Jul 17

ISSN Number

1097-6833

DOI

10.1016/j.jpeds.2018.06.035

Alternate Title

J. Pediatr.

PMID

30029858
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