First name
Maylene
Middle name
Kefeng
Last name
Qiu

Title

Racial and ethnic representation in epigenomic studies of preterm birth: a systematic review.

Year of Publication

2020

Date Published

2020 Dec 02

ISSN Number

1750-192X

Abstract

<p>We conducted a systematic review evaluating race/ethnicity representation in DNA methylomic studies of preterm birth. PubMed, EMBASE, CINHAL, Scopus and relevant citations from 1 January&nbsp;2000 to 30 June&nbsp;2019. Two authors independently identified abstracts comparing DNA methylomic differences between term and preterm births that included&nbsp;race/ethnicity data. 16&nbsp;studies were included. Black and non-Hispanic Black deliveries were well represented (28%). However, large studies originating from&nbsp;more than&nbsp;95% White populations were excluded due to unreported race/ethnicity data. Most studies were cross-sectional, allowing for reverse causation. Most studies were also racially/ethnically homogeneous, preventing direct comparison of DNA methylomic differences across race/ethnicities. In DNA methylomic studies, Black women and infants were well represented. However, the literature has limitations and precludes drawing definitive conclusions.</p>

DOI

10.2217/epi-2020-0007

Alternate Title

Epigenomics

PMID

33264049

Title

Parent Coping Support Interventions During Acute Pediatric Hospitalizations: A Meta-Analysis.

Year of Publication

2017

Date Published

2017 Aug 17

ISSN Number

1098-4275

Abstract

<p><strong>CONTEXT: </strong>Parents may experience psychological distress when a child is acutely hospitalized, which can negatively affect child outcomes. Interventions designed to support parents' coping have the potential to mitigate this distress.</p>

<p><strong>OBJECTIVE: </strong>To describe interventions designed to provide coping support to parents of hospitalized children and conduct a meta-analysis of coping support intervention outcomes (parent anxiety, depression, and stress).</p>

<p><strong>DATA SOURCES: </strong>We searched Pubmed, Embase, PsycINFO, Psychiatry Online, and Cumulative Index to Nursing and Allied Health Literature from 1985 to 2016 for English-language articles including the concepts "pediatric," "hospitalization," "parents," and "coping support intervention."</p>

<p><strong>STUDY SELECTION: </strong>Two authors reviewed titles and abstracts to identify studies meeting inclusion criteria and reviewed full text if a determination was not possible using the title and abstract. References of studies meeting inclusion criteria were reviewed to identify additional articles for inclusion.</p>

<p><strong>DATA EXTRACTION: </strong>Two authors abstracted data and assessed risk of bias by using a structured instrument.</p>

<p><strong>RESULTS: </strong>Initial searches yielded 3450 abstracts for possible inclusion. Thirty-two studies met criteria for inclusion in the systematic review and 12 studies met criteria for inclusion in the meta-analysis. The most commonly measured outcomes were parent depression, anxiety, and stress symptoms. In meta-analysis, combined intervention effects significantly reduced parent anxiety and stress but not depression. Heterogeneity among included studies was high.</p>

<p><strong>LIMITATIONS: </strong>Most included studies were conducted at single centers with small sample sizes.</p>

<p><strong>CONCLUSIONS: </strong>Coping support interventions can alleviate parents' psychological distress during children's hospitalization. More evidence is needed to determine if such interventions benefit children.</p>

DOI

10.1542/peds.2016-4171

Alternate Title

Pediatrics

PMID

28818837

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