<p><strong>CONTEXT: </strong>Parents may experience psychological distress when a child is acutely hospitalized, which can negatively affect child outcomes. Interventions designed to support parents' coping have the potential to mitigate this distress.</p>

<p><strong>OBJECTIVE: </strong>To describe interventions designed to provide coping support to parents of hospitalized children and conduct a meta-analysis of coping support intervention outcomes (parent anxiety, depression, and stress).</p>

<p><strong>DATA SOURCES: </strong>We searched Pubmed, Embase, PsycINFO, Psychiatry Online, and Cumulative Index to Nursing and Allied Health Literature from 1985 to 2016 for English-language articles including the concepts "pediatric," "hospitalization," "parents," and "coping support intervention."</p>

<p><strong>STUDY SELECTION: </strong>Two authors reviewed titles and abstracts to identify studies meeting inclusion criteria and reviewed full text if a determination was not possible using the title and abstract. References of studies meeting inclusion criteria were reviewed to identify additional articles for inclusion.</p>

<p><strong>DATA EXTRACTION: </strong>Two authors abstracted data and assessed risk of bias by using a structured instrument.</p>

<p><strong>RESULTS: </strong>Initial searches yielded 3450 abstracts for possible inclusion. Thirty-two studies met criteria for inclusion in the systematic review and 12 studies met criteria for inclusion in the meta-analysis. The most commonly measured outcomes were parent depression, anxiety, and stress symptoms. In meta-analysis, combined intervention effects significantly reduced parent anxiety and stress but not depression. Heterogeneity among included studies was high.</p>

<p><strong>LIMITATIONS: </strong>Most included studies were conducted at single centers with small sample sizes.</p>

<p><strong>CONCLUSIONS: </strong>Coping support interventions can alleviate parents' psychological distress during children's hospitalization. More evidence is needed to determine if such interventions benefit children.</p>