First name
Matthew
Middle name
D
Last name
Elias

Title

Echocardiographic Findings in Pediatric Multisystem Inflammatory Syndrome Associated with COVID-19 in the United States.

Year of Publication

2020

Date Published

2020 Aug 31

ISSN Number

1558-3597

Abstract

<p><strong>BACKGROUND: </strong>Centers from Europe and United States have reported an exceedingly high number of children with a severe inflammatory syndrome in the setting of COVID-19, which has been termed multisystem inflammatory syndrome in children (MIS-C).</p>

<p><strong>OBJECTIVES: </strong>This study aimed to analyze echocardiographic manifestations in MIS-C.</p>

<p><strong>METHODS: </strong>We retrospectively reviewed 28 MIS-C, 20 healthy controls and 20 classic Kawasaki disease (KD) patients. We reviewed echocardiographic parameters in acute phase of MIS-C and KD groups, and during subacute period in MIS-C group (interval: 5.2 ± 3 days).</p>

<p><strong>RESULTS: </strong>Only 1 case in MIS-C (4%) manifested coronary artery dilatation (z score=3.15) in acute phase, showing resolution during early follow up. Left ventricular (LV) systolic and diastolic function measured by deformation parameters, were worse in MIS-C compared to KD. Moreover, MIS-C patients with myocardial injury (+) were more affected than myocardial injury (-) MIS-C with respect to all functional parameters. The strongest parameters to predict myocardial injury in MIS-C were global longitudinal strain (GLS), global circumferential strain (GCS), peak left atrial strain (LAS) and peak longitudinal strain of right ventricular free wall (RVFWLS) (Odds ratio: 1.45 (1.08-1.95), 1.39 (1.04-1.88), 0.84 (0.73-0.96), 1.59 (1.09-2.34) respectively). The preserved LVEF group in MIS-C showed diastolic dysfunction. During subacute period, LVEF returned to normal (median: from 54% to 64%, p&lt;0.001) but diastolic dysfunction persisted.</p>

<p><strong>CONCLUSIONS: </strong>Unlike classic KD, coronary arteries may be spared in early MIS-C, however, myocardial injury is common. Even preserved EF patients showed subtle changes in myocardial deformation, suggesting subclinical myocardial injury. During an abbreviated follow-up, there was good recovery of systolic function but persistence of diastolic dysfunction and no coronary aneurysms.</p>

<p><strong>CONDENSED ABSTRACT: </strong>Multisystem inflammatory syndrome in children (MIS-C) is an illness that resembles Kawasaki Disease (KD) or toxic shock, reported in children with a recent history of COVID-19 infection. This study analyzed echocardiographic manifestations of this illness. In our cohort of 28 MIS-C patients, left ventricular systolic and diastolic function were worse than in classic KD. These functional parameters correlated with biomarkers of myocardial injury. However, coronary arteries were typically spared. The strongest predictors of myocardial injury were global longitudinal strain, right ventricular strain, and left atrial strain. During subacute period, there was good recovery of systolic function, but diastolic dysfunction persisted.</p>

DOI

10.1016/j.jacc.2020.08.056

Alternate Title

J. Am. Coll. Cardiol.

PMID

32890666

Title

Echocardiographic Assessment of Diastolic Function in Children with Incident Systemic Lupus Erythematosus.

Year of Publication

2019

Date Published

2019 Apr 30

ISSN Number

1432-1971

Abstract

<p>The timing and etiology of diastolic impairment in pediatric-onset systemic lupus erythematosus (SLE) are poorly understood. We compared echocardiographic metrics of left ventricular diastolic function in children at SLE diagnosis to controls and identified factors associated with diastolic indices. Echocardiograms of children aged 5-18&nbsp;years within 1&nbsp;year of SLE diagnosis and age-/sex-matched controls were retrospectively read by blinded cardiologists. Clinical characteristics were abstracted separately. Z-scores for diastolic indices (E/A, e', E/e', and isovolumetric relaxation time (IVRT)) were calculated using published normative data and study controls, and compared using linear mixed-effects models adjusted for blood pressure. Pericardial effusions and valvular disease were also evaluated. Linear regression was used to identify factors associated with diastolic measures. 85 children with incident SLE had echocardiograms performed a median of 6&nbsp;days after diagnosis (interquartile range (IQR) 1-70). Prior cumulative prednisone exposure was minimal (median 60&nbsp;mg, IQR 0-1652). SLE cases had lower E/A, lower e', higher E/e', and longer IVRT compared to controls. Though none met criteria for Grade I diastolic dysfunction, Z-scores for e', E/e', and IVRT were abnormal in 30%, 25%, and 6% of SLE cases, respectively. Greater disease activity was associated with lower septal e' (p &lt; 0.01), higher E/e' (p = 0.02), and longer IVRT (p &lt; 0.01). Children with incident SLE have worse diastolic indices at diagnosis compared to peers without SLE, independent of blood pressure and prior to significant prednisone exposure. Longitudinal studies will determine whether diastolic dysfunction develops in this population over time.</p>

DOI

10.1007/s00246-019-02107-1

Alternate Title

Pediatr Cardiol

PMID

31041461

Title

Prevalence and Risk Factors for Pericardial Effusions Requiring Readmission After Pediatric Cardiac Surgery.

Year of Publication

2016

Date Published

2016 Nov 30

ISSN Number

1432-1971

Abstract

<p>Pericardial effusion (PE) may require readmission after cardiac surgery and has been associated with postoperative morbidity and mortality. We sought to identify the prevalence and risk factors for postoperative PE requiring readmission in children. A retrospective analysis of the Pediatric Health Information System database was performed between January 1, 2003, and September 30, 2014. All patients ≤18&nbsp;years old who underwent cardiac surgery were identified by ICD-9 codes. Those readmitted within 1&nbsp;year with an ICD-9 code for PE were identified. Logistic regression analysis was performed to determine risk factors for PE readmissions. Of the 142,633 surgical admissions, 1535 (1.1%) were readmitted with PE. In multivariable analysis, older age at the initial surgical admission [odds ratio (OR) 1.17, p&nbsp;&lt;&nbsp;0.001], trisomy 21 (OR 1.24, p&nbsp;=&nbsp;0.015), geographic region (OR 1.33-1.48, p&nbsp;≤&nbsp;0.001), and specific surgical procedures [heart transplant (OR 1.82, p&nbsp;&lt;&nbsp;0.001), systemic-pulmonary artery shunt (OR 2.23, p&nbsp;&lt;&nbsp;0.001), and atrial septal defect surgical repair (OR 1.34, p&nbsp;&lt;&nbsp;0.001)] were independent risk factors for readmission with PE. Of readmitted patients, 44.2% underwent an interventional PE procedure. Factors associated with interventions included shorter length of stay (LOS) for the initial surgical admission (OR 0.85, p&nbsp;=&nbsp;0.008), longer LOS for the readmission (OR 1.37, p&nbsp;&lt;&nbsp;0.001), and atrial septal defect surgery (OR 1.40, p&nbsp;=&nbsp;0.005). In this administrative database of children undergoing cardiac surgery, readmissions for PE occurred after 1.1% of cardiac surgery admissions. The risk factors identified for readmissions and interventions may allow for improved risk stratification, family counseling, and earlier recognition of PE for children undergoing cardiac surgery.</p>

DOI

10.1007/s00246-016-1540-2

Alternate Title

Pediatr Cardiol

PMID

27900408

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