First name
Brandon
Middle name
D
Last name
Becker

Title

Patient Reported Outcomes Measurement Information System® (PROMIS(®) ) Tools for Collecting Patient-Reported Outcomes in Children with Juvenile Arthritis.

Year of Publication

2016

Date Published

2016 May 9

ISSN Number

2151-4658

Abstract

OBJECTIVE: To evaluate the precision and construct validity of pediatric Patient Reported Outcomes Measurement Information System(®) (PROMIS(®) ) instruments in a population of juvenile idiopathic arthritis (JIA) patients and parent proxies.

METHODS: A convenience sample of JIA patients and parents of JIA patients completed PROMIS instruments for eight domains: anger, anxiety, depressive symptoms, fatigue, mobility, pain interference, peer relationships, and upper extremity function. Short form and computerized adaptive test (CAT) scores were derived from item bank responses. Raw scores were translated to standardized T-scores with corresponding standard errors (SEs). Discrimination between inactive versus active disease was evaluated as an indicator of each measures' construct validity. SEs were plotted to evaluate each instrument's relative precision. Patient-parent concordance was assessed using intraclass correlations (ICC).

RESULTS: 228 patients and 223 parents participated, providing 71-78 responses per domain. Patient- and parent-reported anger, fatigue, mobility, and pain interference scores significantly differed between those with inactive and active disease. Anxiety, depressive symptoms, and peer relationships differed by disease activity levels for parent-report only. Short forms and CATs provided comparable reliability to the full item banks across the full range of each outcome. Patient-parent agreement ranged from ICC=0.3 to 0.8. CAT did not reduce the number of items for any domain compared to the short form.

CONCLUSION: Precision and discriminatory abilities of PROMIS instruments depend on health domain and report type (self-report versus parent proxy-report) for children with JIA. Varying levels of patient-parent concordance reinforces the importance of considering both perspectives in comprehensive health outcomes assessments. This article is protected by copyright. All rights reserved.

DOI

10.1002/acr.22937

Alternate Title

Arthritis Care Res (Hoboken)

PMID

27159889

Title

Responsiveness of Children's Global Health to Improvements in Acute Asthma.

Year of Publication

2018

Number of Pages

1-22

Date Published

2018 May 01

ISSN Number

1532-4303

Abstract

<p><strong>OBJECTIVE: </strong>To evaluate the reliability and validity of the PROMIS Pediatric Global Health scale, a 7-item measure of perceived physical, mental, and social health, in children with asthma.</p>

<p><strong>METHODS: </strong>From February 2014 to February 2015, convenience samples of children 8-17 years-old (n = 182) and parents of children 5-17 years-old (n = 328) visiting an emergency department for treatment of asthma were enrolled. The Asthma Control Test was used to characterize children as controlled versus not controlled, and the PROMIS Asthma Impact Scale was used to assess the effects of asthma symptoms on functional status. We conducted longitudinal analyses among 92 children and 218 parents at 3 weeks, and 74 children and 171 parents at 8 weeks after enrollment.</p>

<p><strong>RESULTS: </strong>The PGH-7 reliability across the three time points ranged from 0.66 to 0.81 for child-report and 0.76 to 0.82 for parent-proxy. In cross-sectional analyses, children with controlled asthma had PGH-7 scores 0.40-0.95 standard deviation units higher than those who were uncontrolled. The PGH-7 was responsive to changes in overall general health between time points, with moderate effect sizes (0.5-0.6 standard deviation units). In longitudinal analyses, PGH-7 scores were no different between those who stayed uncontrolled versus became controlled at 3 weeks of follow-up; however, by 8 weeks of follow-up, the differences between these groups was 0.7-0.8 standard deviation units, indicative of large effects.</p>

<p><strong>CONCLUSIONS: </strong>The PGH-7 is a reliable and valid patient-reported outcome for assessing general health among children with asthma. It is a useful complement to other asthma-specific outcome measures.</p>

DOI

10.1080/02770903.2018.1471701

Alternate Title

J Asthma

PMID

29712498

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