First name
Ellen
Middle name
R
Last name
Wald

Title

Predictors of Antimicrobial Resistance among Pathogens Causing Urinary Tract Infection in Children.

Year of Publication

2016

Number of Pages

116-21

Date Published

2016 Apr

ISSN Number

1097-6833

Abstract

OBJECTIVE: To determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.

STUDY DESIGN: Children, 2-71 months of age (n = 769) enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux or Careful Urinary Tract Infection Evaluation studies were included. We used logistic regression models to test the associations between demographic and clinical characteristics and resistance to narrow-spectrum antimicrobials.

RESULTS: Of the included patients, 91% were female and 76% had vesicoureteral reflux. The risk of resistance to narrow-spectrum antibiotics in uncircumcised males was approximately 3 times that of females (OR 3.1; 95% CI 1.4-6.7); in children with bladder bowel dysfunction, the risk was 2 times that of children with normal function (OR 2.2; 95% CI 1.2-4.1). Children who had received 1 course of antibiotics during the past 6 months also had higher odds of harboring resistant organisms (OR 1.6; 95% CI 1.1-2.3). Hispanic children had higher odds of harboring pathogens resistant to some narrow-spectrum antimicrobials.

CONCLUSIONS: Uncircumcised males, Hispanic children, children with bladder bowel dysfunction, and children who received 1 course of antibiotics in the past 6 months were more likely to have a urinary tract infection caused by pathogens resistant to 1 or more narrow-spectrum antimicrobials.

DOI

10.1016/j.jpeds.2015.12.044

Alternate Title

J. Pediatr.

PMID

26794472
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Title

Predictors of Non-Escherichia coli Urinary Tract Infection.

Year of Publication

2016

Number of Pages

Date Published

2016 Jul 18

ISSN Number

1532-0987

Abstract

<p>We aimed to determine which children are prone to non-Escherichia coli coli UTIs. We included 769 children with UTI. We found that circumcised males, Hispanic children, children without fever, and children with Grade 3-4 VUR were more likely to have a UTI caused by organisms other than E. coli. This information may guide clinicians in their choice of antimicrobial therapy.</p>

DOI

10.1097/INF.0000000000001301

Alternate Title

Pediatr. Infect. Dis. J.

PMID

27434831
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